Vellkova , re banks , a gearing , et al . serum concentrationof soluble adhesion molecules in patients with colorectal cancer [ j ] . br j cancer , 1998 , 77 ( 11 ) : 1857 陈国玉,丁永斌.血管细胞粘附分子在胃癌中的表达及其临床意义[ j ] .南京医科大学学报, 2001 , 5 : 399 - 402
Being a kind of adhesion molecules associating cells with extracellular matrix , integrins play a variety of roles in the process of invasion and metastasis in pancreatic adenocarcinoma 胰腺癌手术切除率低死亡率高的重要原因之一是肿瘤早期即能发生局部浸润和远处器官转移,整合素作为细胞与细胞外基质的黏附分子,在胰腺癌侵袭及转移过程中发挥多重作用。
Results wmt could inhibit thp1 to huvec adhesion induced by hyperlipidemic serum , and downregulate the expression of icam1 , vcam1 , pselectin on huvec surface , the two disassembled formulas could downregulate different adhesion molecules 结果温脉通能抑制高脂诱导的huvec与thp1的黏附,并下调huvec表面icam1 vcam1 pselectin的表达两拆方组对不同的黏附分子有下调作用。
Nfkb ( nuclear factor kappa b ) transcription factor regulate encoding genes of various cytokines such as growth factors and adhesion molecules . recently , studies have revealed nfkb is relationed to trauma 核转录因子nf b ( nuclearfactorkappab , nf b )是一种重要的生物因子,调控多种细胞因子如生长因子、细胞因子、粘附分子等编码基因的表达,近来研究表明, nf b与创伤关系密切。
One of the proposed functions of the adhesion molecules , so - called adhesion molecules is that recirculating lymphocytes , mono - cytes , and granulocytes bear receptors that bind to adhesion molecules on the vascular endothelium , enabling these cells to extravasate into the tissues 粘附分子之所以称之为粘附分子,是因为其首要功能就是将淋巴细胞、单核细胞及粒细胞粘附在血管内皮细胞上,使其穿越血管内皮,到达炎症反应处。
In 1994 , conry firstly constructed cea dna vaccine , studied its immunological effects and made great achievements . in order to enhance dna vaccine efficacy , researchers are inclined to employ effective and safe vectors , co - delivery cytokines recombinant or adhesion molecules , iss , and so on 1994年, conry郑州大学医学院2002研究生毕业论文癌胚抗原a疫苗构建及佐剂对其兔疫效应的影响就构建了ceadna疫苗,并在动物体内诱导产生了良好的兔疫效果。
Recently , many adhesion molecules have been used in practice of forensic pathology , intercellular adhesion molecule - 1 ( icam - 1 ) and p - selectin are considered to be closely involve in wound healing . the authors immunohistochemically examined the time - dependent expression of icam - 1 and p - selectin 本研究应用免疫组织化学方法,观察大鼠皮肤切创后不同时间细胞间粘附分子( icam - 1 )及p选择素的表达变化,以期确定这两种物质表达与损伤时间变化的规律,为皮肤损伤时间判定提供有效的免疫组织化学指标。
It is well known that various kinds of biological substances such as growth factors , cytokines and adhesion molecules are closely related with the wound healing process . in particular , adhesion molecules play an important role in the promotion of inflammatory reaction , these factors stimulate the synthesis of extracellular matrix by local fibroblasts , generate new blood vessels , promote the granulation tissue fonnation , and enhance re - epithelialization nthat takes places by the migration of the kerati - nocytes from the edges of the wound toward the center 多种生物学介质如:生长因子、细胞因子及粘附分子等与皮肤损伤愈合过程密切相关,尤为值得提出的是,粘附分子在炎症的发生的起始过程中起着至关重要的作用,这些因子在细胞外基质的形成、血管的发生、肉芽组织的生成及上皮的再形成方面等均具有重要作用。
Catenin binds to the cytoplasmic tail of a transmembrane cell adhesion molecule - epithelial cadherin ( e - cadherin ) in epithelial cells and forms an adhesion complex [ e - cadherin - p - catenin ( or y - catenin ) - cc - catenin ] ( cadherin - catenin - complex , ccc ) , this complex play an important role in maintaining epithelial cell adhesion . some catenins such as - , - and p120ctn catenins are also crucial in cell signaling , they play an important role in cell proliferation and cell apoptosis 在上皮细胞内,连环蛋白均能与跨膜细胞粘附分子?上皮钙粘蛋白( e - cadherin )的胞内肽段结合而形成了由上皮钙粘蛋白- -连环蛋白( -连环蛋白) - -连环蛋白组成的粘附连接体( adherensjunctions , ajs ) ,这种复合体对维持细胞正常的粘附功能是必需的。
Heparin is known to bind and modulate the activity of various proteins , including cell growth factors , cytokines , angiogenic factors , complement components , adhesion molecules , heparin exerts its activities via interaction with some proteins . potent anticoagulant activity of heparin by the interaction with antithrombin iii is extensively used in medicine 肝素能够与许多蛋白质结合并调节蛋白活性,包括细胞因子、生长因子、趋化因子、抗血管生成因子、粘附分子和补体成分等,肝素通过与蛋白相互作用发挥其生物学活性。