It was determined that the particle size of haloperidol - loaded plga / pla nanoparticles is effectively controlled by the amount of shear stress transferred from the energy source to the organic phase , which is strongly correlated to the following parameters : type of applied energy , aqueous phase volume , and polymer concentration in the organic solvent 已经确定可通过对有机相的剪切力大小来有效控制氟哌啶醇plga / pla纳米粒的粒径,而这种剪切力大小与下列参数密切相关:所用能量类型,水相体积和有机溶剂中的聚合物浓度。