- second signal
- secondary signal
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第二信号的英文
例句与用法
- To vent shaft 22 on the second quadrant now
到第二信号室22号通风口出口处 - To vent shaft 22 on the second quadrant now
到第二信号室22号通风口出口处 - Effective activation of antigen - specific t cells not only requires the first signal transduction through t - cell receptor ( tcr ) binding with peptide - mhc complex on the antigen presenting cell ( apc ) , but also needs the second signal , termed costimulation . costimulation critical to the degree and consequence of t cell activation is provided by interaction between soluble factors or cell - surface molecules on the t cell and on the apc
而t细胞的活化除需要t细胞受体( tcr )与抗原呈递细胞( antigenpresentingcell , apc )表面的抗原肽- mhc复合物结合所形成的第一信号外，还需要t细胞和apc表面的其它膜分子结合所提供的共刺激信号(亦称第二信号或辅助刺激信号， costimulatorysignal )的参与。 - Dendritic cells ( dc ) is the most powerful apc , which can markedly increase the antigen - presentation capacity by maximizing the pepitide - mhc complexes on the cell surface and upregulating the co - stimulatory ligands b7 - 1 and b7 - 2 , adhesion moleculees such as il - 12 that promote full activation of lymphocytes . full activation of antigen - specific t cells requires two signals - one signal coming via the tcr and the other signal through engagment of co - stimulatary molecules . t cells receiving one signal via their tcr are turned off by mhc ( major histocompatibility complex ) , via t cell cd28 binding to b7 on the dc induce tlymphokine and t cell proliferatiion
T细胞介导的细胞免疫在控制肿瘤生长方面发挥着重要作用， t细胞在发挥抗瘤效应(分泌细胞因子和直接杀伤)之前必须先经过活化，体内专职抗原提呈细胞( apc )细胞并使其活化，树突状细胞( dendriticcell , dc )为t细胞的激活提供双重信号， t细胞借助tcr识别由dcmhc分子递交的抗原肽后，通过tcr - cd3复合体传递抗原特异性识别信号(第一信号) ，以cd28为主的t细胞表面辅佐分子识别dc表面b7分子，传递非特异性协同刺激信号(第二信号) ，在机体抗肿瘤免疫应答中处于核心地位。