A rate - limiting step to long - term survival in heart transplant patients is coronary arteriopathy , which is marked intimal proliferation with lumenal narrowing of the small epicardial and intramyocardial coronary artery branches , leading to ischemic changes 冠状动脉影响到心脏移植病人能否长期存活,它的特征有内膜增生伴有心外膜以及心肌内的冠状动脉分支管腔狭窄,从而导致缺血性改变。
The tolerant state induced by pretreatment of fty was so robust that these long term survivors can accept the skin grafts from the same donors . in the intro study , the characteristic of apoptosis was showed by dna fragmentatation in the mouse splenocytes incubated with fty 淋巴因子检测显示该组中长期存活的小鼠il - 4水平明显升高,显著高于正常小鼠和对照组排斥移植物的小鼠;对照组排斥移植物的小鼠ifn -明显升高,显著高于正常小鼠和长期存活的小鼠。
In terms of regulatory t cell , cd4 + cd25 + t cell is representitive . ln naive individuals , cd4 + cd25 + t cells function as self tolerance , in recipients with long term survival allograft . they play an important role in suppression of allograft rejection . immune regulation potent cd4 + cd25 + t cells can be recovered from recipients with long term survival allografts . such regulatory t cells can suppress t cell mediated rejection in vitro and in vivo 其中, cd4 + cd25 + t细胞是具有代表性的调节性t细胞。在未经处理的机体内, cd4 + cd25 + t细胞对保持自身耐受起着关键的作用。在同种异体移植物长期存活的受体内, cd4 + cd25 + t细胞对抑制同种异体移植物排斥反应也起到很重要的作用。
Objective the aim of this article was to induce long term survival allografts by blocking cd40 - cd40l pathway with homemade anti - cd40l monoclonal antibody mr1 , then purify cd4 + cd25 + regulatory t cells from recipients with long term survival allografts , and adoptively cotransfer such cells together with tcr transgenic allogenic antigen specific cd8 + t cells into immunodeffient mouse . finally study whether cd4 + cd25 + t cells can suppress allogenic antigen specific cd8 + t cell mediated rejection , thus clarified whether cd4 + cd25 + t cell mediated regulation is one of mechanisms of prolongation of allograft survival by cd40 - - cd40l pathway blockade 从移植物长期存活的受体内分选出cd4 + cd25 + t细胞,与tcr转基因cds + t细胞同时过继输注到免疫缺陷小鼠体内,观察co4 + co25 + t细胞对同种异体反应性cos + t细胞介导排斥反应的作用,探讨在阻断cd40se一~ cd40l共刺激途径延长移植物存活中, cd4 + cd25 +调节性丁细胞是否是抑制排斥反应的机制之一。
长期: over a long period of time; ...存活: survival长期存活者: phiv long-term survivors非长期存活者: not-long-term survivor长期存储: long term storage长期存储器: long time memory; long-time memory; ltm long term memory长期存款: long term deposit; long-term deposit长期存款单: long-term certificate of deposit长期存在: exist for long; long-term existence长期存在的: long standing; long-standing可长期存在: long-standing长期存在缺陷: longstanding flaw可长期存在的: long-standing观察的中期存活时间: observed median survival time; omst长期存在的不满: longstanding grievancess长期存在的软弱带: long-standing zone of weakness长期存在的问题: long standing issue; long standing problem长期存在的远景: long-range perspectives长期存储器, 长期记忆, 长时记忆: long-term memory存活: survival◇存活率 survival rate; survival percentage长期: over a long period of time; long-term; long range; secular 作长期打算 take a long view; make long-term plans; 长期观点 a long-term view; 长期存在的问题 a long-standing problem; 这个实验结果长期不显著。 the result of this experiment was not noticeable for a long period.; 长期保险 long term insurance; 长期产品脱销 chronic shortage of some products; 长期储藏 standing storage; 长期储蓄 permanent saving; 长期存款 long-term deposits; 长期贷款 long-term loan; 长期订单 standing order; 长期负债(借款) funded debt;funded liabilities; 长期国策 long-term national policy; 长期居留证 long-term residence permit; 长期徘徊不前 protracted stagnation; 长期失业 chronic unemployment; 长期投资 permanent investment; 长期债券 long-term bonds; 长期债券利率 long rate; 长期债权 long-term claims; 长期债务 funded debt; 长期债务还本付息 payment on long-term debt; 长期资产 long-term assets; funded property;long-lived assets; 长期准许证 standing permit存活包: keepalive packet存活比: survival ratio存活的: eurithermophilic; euryhaline存活力: longevity