No , a first gas information molecule discovered in human being , is a typical endothelial - derived relaxant and mediates endothelium - dependent relaxation of blood vessels . in the pathogesis of endotoxin shock vec is one of the major target cells of lps and lps - induced proinflammatory cytokine such as tumor necrosis factor and interlukin 1 and activated . in vec inducible nitric oxide synthase ( inos ) is induced and lead to an increase in production of no , the while endothelial nitric oxide synthase ( enos ) is inhibited and elicit decrease in no formation , both of which are demonstrated to induce the 在内毒素休克过程中vec是lps及其诱导机体产生的多种促炎细胞因子如tnf 、 il - 1作用的主要靶细胞, vec诱导型一氧化氮合酶( induciblenitricoxidesynthase , inos )激活、 no大量诱生而内皮型一氧化氮合酶( endothelialnitricoxidesynthase , enos )活性被抑制、 no生成障碍,是血管反应性异常变化、血管调节机制紊乱的重要发病环节。
It has been well known that vascular endothelial cells ( vec ) are not only a mechanical and biological barrier of blood vessels , but also an endocrine organ , which maintain vascular normal tension and reactivities througth synthesis and release vasoactive substances such as nitric oxide ( no ) 研究发现,血管内皮细胞( vascularendothelialcells , vec )能合成多种血管活性物质,是维持血管正常张力状态和血管反应性的关键因素。其中vec释放的一氧化氮( nitricoxide , no )是人们发现的机体第一种气体信使分子,具有明显的血管活性、介导了血管内皮依赖性舒张反应。